The War of the League of Cambrai, also known by its second stage as the War of the Holy League, was fought from December 1508 to December 1516, as part of the wider Italian Wars of 1494–1559. The main participants of the war, who fought for its entire duration, were France, the Holy Roman Empire, the Papal States, and the Republic of Venice; they were joined at various times by nearly every significant power in Western Europe, including Spain, England, the Duchy of Milan, the Republic of Florence, the Duchy of Ferrara, and the Swiss.