The Khanate of Bukhara was an Uzbek monarchy in Central Asia from 1501 to 1785, founded by the Shaybanid dynasty, a branch of the Abu'l-Khayrids. Muhammad Shaybani, grandson of the steppe ruler Abu'l Khayr Khan, conquered the major cities of Mawarannahr (Transoxiana) – Balkh, Bukhara, Samarkand, and Tashkent – and established his rule in the region. In its earliest years, the Khanate was alternately governed from each of these cities before Abdullah Khan II established Bukhara as its permanent capital by 1562.