The Crow Creek Indian Reservation, home to Crow Creek Sioux Tribe is located in parts of Buffalo, Hughes, and Hyde counties on the east bank of the Missouri River in central South Dakota in the United States. It has a land area of 421.658 square miles (1,092.09 km2) and a 2000 census population of 2,225 persons. The major town and capital of the federally recognized Crow Creek Sioux Tribe is Fort Thompson.