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The Opening of the Fifth Seal was painted in the last years of El Greco's life for a side-altar of the church of Saint John the Baptist outside the walls of Toledo. Before 1908, El Greco's painting had been referred to as Profane Love. The scholar Manuel B. Cossio had doubts about the title and suggested the Opening of the Fifth Seal. The Metropolitan Museum, where the painting is kept, comments: "the picture is unfinished and much damaged and abraded."

