The Diocletianic or Great Persecution was the last and most severe persecution of Christians in the Roman Empire. In 303, the emperors Diocletian, Maximian, Galerius, and Constantius issued a series of edicts rescinding Christians' legal rights and demanding that they comply with traditional religious practices. Later edicts targeted the clergy and demanded universal sacrifice, ordering all inhabitants to sacrifice to the Roman gods. The persecution varied in intensity across the empire—weakest in Gaul and Britain, where only the first edict was applied, and strongest in the Eastern provinces. Persecutory laws were nullified by different emperors at different times. Traditionally, the reign of Constantine the Great and Licinius' Edict of Milan in 313 have marked the end of the persecution.