The Battle of Issus occurred in southern Anatolia, on 5 November 333 BC between the Hellenic League led by Alexander the Great and the Achaemenid Empire, led by Darius III. It was the second major battle in Alexander's invasion of the Persian empire, and the first encounter between Darius III and Alexander the Great. The battle resulted in the Macedonian troops defeating the Persian forces. Darius was forced to flee, leaving behind his family and treasury which were captured by Alexander the Great.